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Therapeutic resistance in cancer treatment can be divided into primary resistance (lack of response to initial therapy due to preexisting genetic mutations) and acquired resistance (relapse despite initial response, caused by intratumor heterogeneity and other factors). While genetic alterations are known to contribute to acquired resistance, recent evidence suggests the involvement of non-genetic adaptive mechanisms.

@BodenmillerLab Precision Oncology keynote lecture
at the Life Science Zurich Impact Conference DATA FOR HEALTH 23 May 2023, at the Technopark Zurich.

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